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What is NiBetaSeries?

NiBetaSeries is BIDS-compatible application that calculates betaseries correlations. In brief, a beta coefficient (i.e., parameter estimate) is calculated for each trial (or event) resulting in a series of betas (“betaseries”) that can be correlated across regions of interest.

Why should I use it?

There are potential insights hidden in your task fMRI data. Rest fMRI enjoys a multitude of toolboxes which can be applied to task fMRI with some effort, but there are not many toolboxes that focus on making betaseries. Betaseries can then be used for correlations/classifications and a multitude of other analyses. While a couple alternatives exist (pybetaseries and BASCO), NiBetaSeries is the only application to interface with BIDS organized data with the goal of providing a command-line application experience like fMRIPrep.

What does NiBetaSeries give me?

Currently NiBetaSeries returns the beta series images and optionally symmetric z-transformed correlation matrices with an entry for each parcel defined in the atlas.


The betas (i.e., parameter estimates) are generated using either the “Least Squares Separate” or “Least Squares All” procedures. Please read the Beta series page for more background information.

What do I need to run NiBetaSeries?

NiBetaSeries takes BIDS and preprocessed data as input that satisfy the BIDS derivatives specification. In practical terms, NiBetaSeries uses the output of fMRIPrep, a great BIDS-compatible preprocessing tool. NiBetaSeries requires the input and the atlas to already be in the same space (e.g., MNI space). For more details, see Usage and the tutorial (Running NiBetaSeries)

Get Involved

This is a very young project that still needs some tender loving care to grow. That’s where you fit in! If you would like to contribute, please read our Code of Conduct and contributing page (Contributing to NiBetaSeries).